Infuse intravenously according to the weight of the child (see table).įor example for a child weighing 12 kg, Dose 1 is infused at 38mL/h over 60 minutes, Dose 2 would be infused at 25mL/h and Dose 3 at 13mL/h.ĭoses should be administered sequentially with no break between the doses.ġ Dose calculations are based on the weight in the middle of each band. A separate volume will be required for each of the three infusion periods.įor example for a child weighing 12 kg, 38mL of solution is required for Dose 1, 100mL for Dose 2 and 200mL for Dose 3. Dilute each 10 mL ampoule of N-acetylcysteine (200 mg/mL) with 310 mL glucose 5% or sodium chloride 0.9% to give a total volume of 320 mL.Īny unused solution should be disposed of in accordance with local requirements.ĭetermine the total volume of solution to be infused (infusion fluid + N-acetylcysteine prepared as above) into the child from the table. Dilute each 10mL ampoule of N-acetylcysteine (200 mg/mL) with 30 mL glucose 5% or sodium chloride 0.9% to give a total volume of 40 mL. Given as a 6.25 mg/mL solution at a rate of 1 mL/kg/h. Given as a 6.25 mg/mL solution at a rate of 2 mL/kg/h.ĭose: 100 mg/kg infused over 16 hours (6.25 mg/kg/h). Given as a 50 mg/mL solution at a rate of 3 mL/kg/h.ĭose: 50 mg/kg infused over 4 hours (12.5 mg/kg/h). Initial loading dose of 150 mg/kg infused over 1 hour (150 mg/kg/h). The full course of treatment with N-acetylcysteine comprises 3 consecutive intravenous infusions: Sodium Chloride 0.9% solution may be used if Glucose 5% is not suitable.ĭoses should be administered using an appropriate infusion pump. N-acetylcysteine should be administered by intravenous infusion preferably using Glucose 5% as the infusion fluid. Please circle appropriate weight, dose and volume.Ģ00 mLs 5% glucose or sodium chloride 0.9%ĥ00 mLs 5% glucose or sodium chloride 0.9%ġ000 mLs 5% glucose or sodium chloride 0.9%ġ Dose calculations are based on the weight in the middle of each band.Ģ Ampoule volume has been rounded up to the nearest whole number.Ĭhildren should be treated with the same doses and regimen as adults however, the quantity of intravenous fluid used should be modified to take into account age and weight, as fluid overload is a potential danger. (each ampoule = 200mg/mL N-acetylcysteine)
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